Staff Profile
Sarah Pagan
Lab Manager
- Email: [email protected]
- Telephone: 0191 2082795
- Personal Website: https://research.ncl.ac.uk/hilab/
- Address: Haematopoiesis and Immunogenomics Lab
Translational & Clinical Research Institute
M3.127, 3rd Floor Leech Building
Newcastle University
Framlington Place
Newcastle upon Tyne
NE2 4HH
Publications
- Cytlak U, Resteu A, Pagan S, Green K, Milne P, Maisuria S, McDonald D, Hulme G, Filby A, Carpenter B, Queen R, Hambleton S, Hague R, Lango Allen H, Thaventhiran JED, Doody G, Collin M, Bigley V. Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans. Immunity 2020, 53(2), 353-370.
- Jardine L, Cytlak U, Gunawan M, Reynolds G, Green K, Wang XN, Pagan S, Paramitha M, Lamb CA, Long A, Hurst E, Nair S, Jackson GH, Publicover A, Bigley V, Haniffa M, Simpson AJ, Collin M. Donor monocyte-derived macrophages promote human acute graft-versus-host disease. The Journal of Clinical Investigation 2020, 130(9), 4574-4586.
- Milne P, Wilhelm-Benartzi C, Grunwald MR, Bigley V, Dillon R, Freeman SD, Gallagher K, Publicover A, Pagan S, Marr H, Jones GL, Dickinson AM, Grech A, Burnett AK, Russell NH, Levis M, Knapper S, Collin M. Serum Flt3 ligand is a biomarker of progenitor cell mass and prognosis in acute myeloid leukemia. Blood Advances 2019, 3(20), 3052-3061.
- Hardie C, Green K, Jopson L, Millar B, Innes B, Pagan S, Tiniakos D, Dyson J, Haniffa M, Bigley V, Jones DE, Brain J, Walker LJ. Early Molecular Stratification of High-risk Primary Biliary Cholangitis. EBioMedicine 2016, 14, 65-73.
- Hardie C, Green KJ, Pagan S, Dyson JK, Walker LJ, Jopson L, Jones D, Brain JG. High-risk primary biliary cirrhosis has a distinct molecular signature opening the way for a molecular approach to stratified therapeutics. In: 66th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting. 2015, San Francisco, CA, USA: Wiley-Blackwell Publishing Ltd.
- Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, Haniffa M, Collin M. Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells. Journal of Leukocyte Biology 2015, 97(4), 627-634.
- Aljefri K, Wang XN, Husain A, Bacon C, Long A, Pagan S, Collin M, Haniffa M. Factor XIIIa identifies macrophages and cells of mesenchymal origin in the human skin. In: British Society of Investigative Dermatology Annual Meeting. 2014, Newcastle upon Tyne: Wiley-Blackwell Publishing Ltd.
- McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Saavedra DM, Larbi A, Wasan PS, Duan K, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M. Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages. Immunity 2014, 41(3), 465-477.
- McGovern N, Schlitzer A, Gunawan M, Jardine L, Shin A, Poyner E, Green K, Dickinson R, Wang XN, Low D, Best K, Covins S, Milne P, Pagan S, Aljefri K, Windebank M, Miranda-Saavedra D, Wasan P, Kaibo D, Poidinger M, Bigley V, Ginhoux F, Collin M, Haniffa M. Human tissue mononuclear phagocyte system revisited. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell Publishing Ltd.
- Dickinson RE, Milne P, Pagan S, Bigley V, Collin M. Reduced GATA-2 expression in individuals with DCML deficiency. In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell Publishing Ltd.
- Dickinson RE, Milne P, Jardine L, Zandi S, Swierczek SI, McGovern N, Cookson S, Ferozepurwalla Z, Langridge A, Pagan S, Gennery A, Heiskanen-Kosma T, Hamalainen S, Seppanen M, Helbert M, Tholouli E, Gambineri E, Reykdal S, Gottfreosson M, Thaventhiran JE, Morris E, Hirschfield G, Richter AG, Jolles S, Bacon CM, Hambleton S, Haniffa M, Bryceson Y, Allen C, Prchal JT, Dick JE, Bigley V, Collin M. The evolution of cellular deficiency in GATA2 mutation. Blood 2014, 123(6), 863-874.
- Wang X, McGovern N, Windebank M, Pagan S, Bigley V, Shin A, Ginhoux F, Lim H, Angeli V, Collin M, Haniffa M. Microanatomical dissection of the human dermis: The relationship between antigen presenting cells, lymphatic and blood vessels. In: 2013 International Investigative Dermatology Meeting. 2013, Edinburgh, Scotland: Nature Publishing Group.
- Jardine L, Barge D, Ames-Draycott A, Pagan S, Cookson S, Spickett G, Haniffa M, Collin M, Bigley V. Rapid detection of dendritic cell and monocyte disorders using CD4 as a lineage marker of the human peripheral blood antigen-presenting cell compartment. Frontiers in Immunology 2013, 4(4), 495.
- Jardine L, Hambleton S, Bigley V, Pagan S, Wang X-N, Collin M. Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands. Leukemia and Lymphoma 2013, 54(1), 167-173.
- Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, Wasan PS, Wang XN, Malinarich F, Malleret B, Larbi A, Tan P, Zhao H, Poidinger M, Pagan S, Cookson S, Dickinson R, Dimmick I, Jarrett RF, Renia L, Tam J, Song C, Connolly J, Chan JK, Gehring A, Bertoletti A, Collin M, Ginhoux F. Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells. Immunity 2012, 37(1), 60-73.
- Haniffa M, Shin A, Bigley V, McGovern N, Wang XN, Teo P, Sng D, Won JM, Marinarich FG, Malleret B, See P, Larbi A, Zhou H, Poidinger M, Pagan S, Cookson S, Dickinson R, Connolly J, Gehring A, Bertoletti A, Collin M, Ginhoux F. CD141(+) human migratory dendritic cells are homologous to murine CD103+dendritic cells and excel at exogenous antigen cross-presentation. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
- Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern N, Spence L, Pagan S, Carey C, Dimmick I, Chua I, Wallis J, Lordan J, Morgan C, Kumararatne DS, Doffinger R, van der Burg M, van Dongen J, Cant A, Jackson G, Dick JE, Hambleton S, Collin M. Dendritic cell, monocyte, B and NK lymphoid deficiency: a novel but potentially fatal haematological disorder curable with haematopoietic stem cell transplantation. In: Bone Marrow Transplantation: 37th European Group for Bone and Marrow Transplantation. 2011, Paris, France: Nature Publishing Group.
- Dickinson RE, Griffin H, Bigley V, Reynard LN, Hussain R, Haniffa M, Lakey JH, Rahman T, Wang XN, McGovern N, Pagan S, Cookson S, McDonald D, Chua I, Wallis J, Cant A, Wright M, Keavney B, Chinnery PF, Loughlin J, Hambleton S, Santibanez-Koref M, Collin M. Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood 2011, 118(10), 2656-2658.
- McGovern N, Bigley V, Allen C, Haniffa M, Wang XN, Dickinson R, Pagan S, Windebank K, McClain K, Ginhoux F, Merad M, Collin M. Human Langerin plus dendritic cells are independent of epithelial Langerhans cells; a novel perspective on Langerhans cell histiocytosis. In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
- Sturgess K, Slatter M, Bigley V, Haniffa M, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Chua I, Wallis J, Lordan J, Morgan C, Cant A, Gennery A, Edmondson R, Bacon C, Black F, Kirkham N, Jackson GH, Hambleton S, Collin MP. Reduced Intensity Hematopoietic Stem Cell Transplant Rescues Immune Function and Corrects Pulmonary Alveolar Proteinosis in DCML Deficiency/GATA 2 Mutation. In: Blood: 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH). 2011, San Diego, California, USA: American Society of Hematology.
- Bigley V, Haniffa M, Doulatov S, Wang XN, Dickinson R, McGovern N, Jardine L, Pagan S, Dimmick I, Chua I, Wallis J, Lordan J, Morgan C, Kumararatne DS, Doffinger R, van der Burg M, van Dongen J, Cant A, Dick JE, Hambleton S, Collin M. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. Journal of Experimental Medicine 2011, 208(2), 227-234.