Staff Profile

Areas of Expertise

·        Cancer drug discovery

·        Target validation

·        Small molecule inhibitors

·        Tumour Microenvironment

Qualifications

·        BSc (Honours), Newcastle University, 2015

·        MRes, Newcastle University, 2016

·        PhD, Newcastle University, 2019

·        FHEA Fellow of the Higher Education Academy, University of Southampton, 2022

Previous Positions Professional Association

·        Postdoctoral Research Fellow, Cancer Sciences, University of Southampton, 2020-2023

Professional Association

·        World Cancer Research Fund Academy Fellow, 2019-present

Honours and Awards

·        Pseudomyxoma Survivor Charity - Hampshire Hospitals NHS Trust: ‘Molecular Characterisation of Pseudomyxoma Peritonei’ £50,000

Dr Breininger is a project supervisor to undergraduate and postgraduate students of Newcastle University and externally.

Dr Breininger lectures in modules ‘Foundations of Medicine’ and ‘Locomotor’ at the University of Southampton.

• Articles

  • Sharpe BP, Hayden A, Manousopoulou A, Cowie A, Walker RC, Harrington J, Izadi F, Breininger SP, Gibson J, Pickering O, Jaynes E, Kyle E, Saunders JH, Parsons SL, Ritchie AA, Clarke PA, Collier P, Mongan NP, Bates DO, Yacqub-Usman K, Garbis SD, Walters Z, Rose-Zerilli M, Grabowska AM, Underwood TJ. Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts. Cell Reports Medicine 2022, 3(6), 100541.
  • Breininger SP, Sabater L, Malcomson FC, Afshar S, Mann J, Mathers JC. Obesity and Roux-en-Y gastric bypass drive changes in miR-31 and miR-215 expression in the human rectal mucosa. International Journal of Obesity 2022, 46, 333-341.
  • Izadi F, Sharpe BP, Breininger SP, Secrier M, Gibson J, Walker RC, Rahman S, Devonshire G, Lloyd MA, Walters ZS, Fitzgerald RC, Rose-Zerilli MJJ, Underwood TJ. Genomic analysis of response to neoadjuvant chemotherapy in esophageal adenocarcinoma. Cancers 2021, 13(14), 3394.
  • Breininger SP, Malcomson FC, Afshar S, Turnbull DM, Greaves L, Mathers JC. Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk. Proceedings of the Nutrition Society 2019, 78(3), 426-437.
  • Malcomson FC, Breininger SP, ElGendy K, Joel A, Ranathunga T, Hill TR, Bradburn DM, Turnbull DM, Greaves LC, Mathers JC. Design and baseline characteristics of the Biomarkers Of Risk In Colorectal Cancer (BORICC) Follow-Up study: A 12+ years follow-up. Nutrition and Health 2019, 25(3), 231-238.

• Reviews

  • Murage NW, Ahmed NM, Underwood TJ, Walters ZS, Breininger SP. The genetic profile and molecular subtypes of human pseudomyxoma peritonei and appendiceal mucinous neoplasms: a systematic review. Cancer and Metastasis Reviews 2023, 42(1), 335-359.
  • Lang CCJ, Lloyd M, Alyacoubi S, Rahman S, Pickering O, Underwood T, Breininger SP. The Use of miRNAs in Predicting Response to Neoadjuvant Therapy in Oesophageal Cancer. Cancers 2022, 14(5), 1171.
  • Pickering OJ, Breininger SP, Underwood TJ, Walters ZS. Histone modifying enzymes as targets for therapeutic intervention in oesophageal adenocarcinoma. Cancers 2021, 13(16), 4084.